WILMINGTON, Del. — The coronavirus action plan President Joe Biden is unveiling Thursday aims to bring new urgency to the nation’s vaccination campaign coupled with another round of economic relief for hunkered-down Americans.

The Biden plan comes as a divided nation remains caught in the grip of the pandemic’s most dangerous wave yet. So far, more than 385,000 have died in the U.S. And government numbers out Thursday reported a jump in weekly unemployment claims, to 965,000, a sign that rising infections are forcing businesses to cut back and lay off workers.

Biden hopes his multipronged strategy, to be detailed in a Thursday evening speech, will put the country on the path to recovery by the end of his first 100 days. “It’s going to be hard,” Biden said Monday after he got his second vaccine shot. “It’s not going to be easy. But we can get it done.”

A more disciplined focus on vaccination is the new and widely anticipated game-changing element, but that’s far from the whole story. Biden is asking Americans to override their sense of pandemic fatigue and recommit to wearing masks, practicing social distancing, and avoiding indoor gatherings, particularly larger ones. That’s still the surest way to brake the COVID-19 wave, with more than 4,400 deaths reported just on Tuesday.

He’s also expected to ask Congress for another round of economic relief. Biden has already tweeted his support for a $2,000 stimulus check, saying that the previous check of $600 was “not enough when you have to choose between paying rent or putting food on the table.”

Senate Democratic leader Chuck Schumer of New York said the Biden COVID-19 package will be the first order of business this year. Democrats expect it will also include more aid for unemployed workers as well as money for state efforts to contain the pandemic and sustain basic services.

But Biden’s biggest challenge is to “win the hearts and minds of the American people to follow his lead,” said Dr. Leana Wen, a public health expert and emergency physician.

Biden Has Set a Goal of Administering 100 Million Shots in His First 100 Days

With the backing of Congress and the expertise of private and government scientists, the Trump administration has delivered two highly effective vaccines and more are on the way. Yet a month after the first shots were given, the nation’s vaccination campaign is off to a slow start with about 10.3 million people getting the first of two shots, although more than 29 million doses have been delivered.

Biden aims to speed that up by delivering more vaccine and working closely with states and local communities to get shots into the arms of more people. The Trump administration provided the vaccine to states and set guidelines for who should get priority for shots, but largely left it up to state and local officials to organize their vaccination campaigns.

“This is going to entail coordination at all levels, as well as resources,” said Dr. Nadine Gracia, executive vice president of the nonpartisan Trust for America’s Health. “There is a commitment the (incoming) administration has articulated to address the needs of communities.”

Biden has set a goal of administering 100 million shots in his first 100 days. The pace of vaccination is approaching 1 million shots a day, but 1.8 million a day would be needed to reach widespread or “herd” immunity by the summer, according to a recent estimate by the American Hospital Association. Wen says the pace should be even higher — closer to 3 million a day.

President Donald Trump repeatedly asserted the coronavirus would go away on its own. Early on, he said it would disappear with warmer weather, and later he said after the election. But Biden sees the pandemic on the level of an existential threat. “That’s my No. 1 concern, to get the virus under control,” he said last week.

Biden Has Pledged to Take His Lead From Science

At the pinnacle of power, Trump’s leadership during the pandemic has been erratic. He did back “Operation Warp Speed ” to quickly develop vaccines and treatments, but he also picked fights with leading government scientists like Dr. Anthony Fauci and his own appointees at the Food and Drug Administration and the Centers for Disease Control and Prevention.

Biden has pledged to take his lead from science, and has named Fauci, head of the National Institute of Allergy and Infectious Diseases, as his top medical adviser. He has tapped businessman Jeff Zients, who has a reputation for successfully tackling complex missions, to coordinate the government’s coronavirus response. He’s also selected Yale medicine professor Dr. Marcella Nunez-Smith, to head an effort to ensure equity and fairness for racial and ethnic minorities in access to vaccines and treatments.

But he’ll need more than top-resume talent, experts say. It’s still unclear how the new administration will address the issue of vaccine hesitancy, the doubts and suspicions that keep many people from getting a shot. Polls show it’s particularly a problem among Black Americans. “It’s important to acknowledge the reasons why it exists and work to earn trust and build vaccine confidence in communities,” said Gracia.

Next Wednesday, when Biden will be sworn in as president, marks the one-year anniversary of the first confirmed case of COVID-19 in the United States.