Week 4 of the 2025 NFL season begins with an NFC West showdown between the Seattle Seahawks and Arizona Cardinals.

Both teams come in with 2-1 records in what looks like a loaded division. Both teams’ only loss came to NFC West leaders San Francisco in one score games.

Seattle is a slight road favorite in what is supposed to be one of the most competitive games of the week.

What Time Is Thursday Night Football?

The game featuring the Seattle Seahawks at the Arizona Cardinals starts at 5:15 p.m. PT/7:15 p.m. MT from State Farm Stadium in Glendale.

What Channel Is Thursday Night Football On?

The game will stream on Amazon Prime.

Seahawks at Cardinals Odds

Seattle -1 1/2. Over-under 43 1/2. Seattle is -125 on the money line, Arizona is +105.

Seahawks at Cardinals Predictions

The line: Seattle 23, Arizona 21. With a line of 1 1/2 points and an over-under of 43 1/2, the Seahawks are expected to win 23-21 or 22-21.

The Arizona Republic: Seahawks 24, Cardinals 17

Jeremy Cluff writes: “This is a pivotal NFC West rivalry game on ‘Thursday Night Football.’ The Cardinals will even wear their new ‘Rivalries’ jersey in it. It won’t help them get a victory. Arizona will miss James Conner in a loss to a Seattle team that is starting to find its stride.”

Bookies.com: Bet the Seahawks on the Moneyline vs Cardinals

Bill Speros writes: “Only Kirk Herbstreit’s dog Pete can save this one. A dog to begin our NFL Week 4 Best Bets. Sam Darnold continues to amaze in the Emerald City in the same way he wowed fans in Minnesota last season.”

Sports Betting Dime: Cardinals 16.3, Seahawks 16.2

The site’s formula predicts that the Cardinals will win the NFL Week 4 game against the Seahawks.

ESPN: Cardinals Have a 52.3% Chance to Beat Seahawks on Thursday Night Football

The site gives the Seahawks a 47.3% shot at winning the NFL Week 4 game, with the remaining percentage accounting for a tie.

Dimers: Cardinals 24, Seahawks 22

It writes: “After extensive simulations, our model gives the Seahawks a win probability of 41%, while the Cardinals have a win probability of 59%.”

Sportsnaut: Seahawks 20, Cardinals 17

Matt Johnson writes: “Defense is king in the NFC West right now. Entering Week 4, three of the four defenses (Seattle Seahawks, Arizona Cardinals and San Francisco 49ers) rank top-five in scoring defense while the Los Angeles Rams are fifth in total yards allowed. So, we expect a defensive battle on Thursday Night Football between Arizona and Seattle. The Seahawks’ run defense has been great at stopping the run (3.2 ypc) … and it has the secondary to really cause problems for this Cardinals’ passing game. Ultimately, critical third-down stops and a takeaway by this Seahawks’ defense pave the way to a victory.”

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Bret Bloomquist can be reached at bbloomquist@elpasotimes.com; @Bretbloomquist on X.
This article originally appeared on El Paso Times: What channel is Thursday Night Football on? Seahawks at Cardinals, how to watch, predictions
Reporting by Bret Bloomquist, El Paso Times / El Paso Times
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