Please ensure Javascript is enabled for purposes of website accessibility

US Electric Vehicle Tax Breaks Will Expire on Sept. 30

4 hours ago

‘Reservoir Dogs’ and ‘Kill Bill’ Actor Michael Madsen Dies at 67

4 hours ago

Eyeing Arctic Dominance, Trump Bill Earmarks $8.6 Billion for US Coast Guard Icebreakers

5 hours ago

Trump’s Sweeping Tax-Cut and Spending Bill Wins Congressional Approval

5 hours ago

Americans Celebrate Their Independence With Record-Breaking Travel Numbers

8 hours ago

US Supreme Court to Decide Legality of Transgender School Sports Bans

9 hours ago

Nvidia Set to Become the World’s Most Valuable Company in History

9 hours ago

Poll: 41% in US ‘Extremely Proud’ to Be American, Near Historic Low

10 hours ago
UCSF Fresno Study: Stem Cell Treatment Aids COVID Patients with Damaged Lungs
News
By News
Published 4 years ago on
September 13, 2021

Share

A UCSF Fresno study of the safety and efficacy of adipose-derived stem cells as a potential treatment for COVID -19 patients who have serious lung damage has shown promising benefits and has prompted further study internationally and at UCSF Fresno.

UCSF Fresno was selected as the only site for the phase 1 of this study, COVID-19 Stem Cell Therapy: A Phase 1 Study of Intravenous Administration of Allogenic Adipose Stem Cells. The study, led by Eyad Almasri, MD, a faculty member at UCSF Fresno, enrolled 10 patients with acute respiratory distress syndrome (ARDS) who had moderate or severe illness. Each received three intravenous infusions of stem cells on three separate days.

(Editor’s Note: This article was written by UCSF Fresno health reporter Barbara Anderson. You can read other UCSF Fresno news at this link.)

These COVID-19 patients all had serious and life-threatening ARDS and were struggling to breathe. With ARDS, tiny air sacs in the lungs fill up with fluid, reducing the lungs’ ability to transport oxygen into the blood. And in severe cases, the body’s immune system responds by flooding the lungs with inflammatory cells and proteins, further restricting passage of oxygen into the blood and to organs.

The hope is the adipose stem cells, collected from an adult donor, will reduce lung inflammation when infused in a patient. Studies have shown allogenic mesenchymal stem cells (MSC) — adult stem cells that are present in bone marrow but can also be obtained from fat tissue — may be effective at stopping an inflammatory overreaction (called a cytokine storm) in the lungs. MSC cells “work like a sponge to absorb the inflammatory proteins and reduce the inflammation cascade in the lung,” said Dr. Almasri, a UCSF associate clinical professor and faculty member at the Department of Internal Medicine — Pulmonary and Critical care and Sleep Medicine who also serves as the assistant dean for research at UCSF Fresno.

Patients for the study were chosen who were not on mechanical ventilation yet but whose lung functions were severely compromised by ARDS. “This was presented as a potential option for people who are not improving or people who are getting worse quickly,” Dr. Almasri said.

No Deaths Among Study Participants

Mortality for patients with severe ARDS who require mechanical ventilation is as high as 39%. The expected mortality for patients with moderate ARDS is 20-30% and of the 10 patients with ARDS enrolled in the UCSF study, two or three would be expected to die, Dr. Almasri said.

“We had no deaths,” he said. All 10 patients were discharged from Community Regional Medical Center after completing treatment with stem cells and were followed for three months. “Our last patient just passed his 90-day safety check,” he said.

A 53-year-old from Fresno was one of 10 patients enrolled in the UCSF Fresno Phase 1 stem cell study. The patient thought a cough that wouldn’t go away at New Year’s was the flu, but a test for COVID-19 came back positive and within days the virus had attacked his lungs. He couldn’t breathe, even on home oxygen borrowed from his mother. His family called for an ambulance and he was taken to Community Regional.

The patient had no hesitation about joining the UCSF Fresno stem cell study. “I’ll do anything. I’m trying to get better. And anything that might work for me is good,” he said.” Three days after the stem cell infusions, his oxygen requirement dropped from 6 liters per minute to 2 per minute and he was sent home on 2 liters of oxygen.

The swift turnaround surprised the research team, Dr. Almasri said. “He had very clear, quick and more than expected improvement.”

Dr. Almasri cautioned the UCSF Fresno study is a small sample and conclusions cannot be drawn from it because it could be pure chance. “But the mortality was lower than what we would have expected,” he said.

Phase 2 of Study Gets Green Light

Results from the UCSF Fresno study have sparked interest among other researchers. Based on two case studies from the UCSF Fresno clinical trial presented to the U.S. Food and Drug Administration and from testimony by Dr. Almasri before the Brazilian Health Regulatory Agency, a Phase 2 COVID-19 stem cell clinical trial won approval to begin in Brazil this June.

Evidence from the Phase 1 trial at UCSF Fresno also was enough for the Food and Drug Administration to give a green light to UCSF Fresno to submit a proposal for a Phase 2 clinical trial that will be a double-blinded randomized study, meaning some patients will receive stem cell infusions and others will receive a placebo. Dr. Almasri and the research team will not know which patients receive the stem cells.

The Phase 2 stem cell study is one of the latest in a string of COVID-19-related research projects at UCSF Fresno. Many of the studies have been led by Dr. Almasri and others at UCSF Fresno.

RELATED TOPICS:

DON'T MISS

What Are Fresno Real Estate Experts Predicting for 2025 and Beyond?

DON'T MISS

First California EV Mandates Hit Automakers This Year. Most Are Not Even Close

DON'T MISS

Fresno Crash Involving Unlicensed Teen Driver Sends Woman to Hospital

DON'T MISS

Madre Fire Burns More Than 52,000 Acres in San Luis Obispo County

DON'T MISS

RIP John Harris: Fresno County Rancher, Racehorse Breeder Was a Visionary Leader Who Leaves a ‘Profound Legacy’

DON'T MISS

Valadao, Costa Spar on What Passage of Trump’s Bill Means for Medicaid Recipients

DON'T MISS

US Military Says 200 Marines Being Sent to Support ICE in Florida

DON'T MISS

Boeing Secures $2.8 Billion US Satellite Contract

DON'T MISS

Kaweah Health Names Its New Chief Nurse. She’s From Texas

DON'T MISS

Clovis Police Say At-Risk Missing Woman Found Dead in Mariposa County

DON'T MISS

Over 100 Former Senior Officials Warn Against Planned Staff Cuts at US State Department

DON'T MISS

US Electric Vehicle Tax Breaks Will Expire on Sept. 30

UP NEXT

RIP John Harris: Fresno County Rancher, Racehorse Breeder Was a Visionary Leader Who Leaves a ‘Profound Legacy’

UP NEXT

Valadao, Costa Spar on What Passage of Trump’s Bill Means for Medicaid Recipients

UP NEXT

Kaweah Health Names Its New Chief Nurse. She’s From Texas

UP NEXT

Clovis Police Say At-Risk Missing Woman Found Dead in Mariposa County

UP NEXT

Fresno Police Recover Some of the $40,000 in Fireworks Stolen From Bullard High Team

UP NEXT

Riverdale High School Coach Arrested for Allegedly Arranging to Meet Minor

UP NEXT

Could Cuddly Colby Be the Darling Gem for You?

UP NEXT

Valley Crime Stoppers’ Most Wanted Person of the Day: Sandra Neredia Jaquez

UP NEXT

Trump Impounds Billions in Education Funding. For Fresno Unified, It’s $7.1 Million

UP NEXT

Americans Celebrate Their Independence With Record-Breaking Travel Numbers

Valadao, Costa Spar on What Passage of Trump’s Bill Means for Medicaid Recipients

2 hours ago

US Military Says 200 Marines Being Sent to Support ICE in Florida

2 hours ago

Boeing Secures $2.8 Billion US Satellite Contract

2 hours ago

Kaweah Health Names Its New Chief Nurse. She’s From Texas

3 hours ago

Clovis Police Say At-Risk Missing Woman Found Dead in Mariposa County

3 hours ago

Over 100 Former Senior Officials Warn Against Planned Staff Cuts at US State Department

3 hours ago

US Electric Vehicle Tax Breaks Will Expire on Sept. 30

4 hours ago

‘Reservoir Dogs’ and ‘Kill Bill’ Actor Michael Madsen Dies at 67

4 hours ago

Fresno Police Recover Some of the $40,000 in Fireworks Stolen From Bullard High Team

4 hours ago

Eyeing Arctic Dominance, Trump Bill Earmarks $8.6 Billion for US Coast Guard Icebreakers

5 hours ago

Fresno Crash Involving Unlicensed Teen Driver Sends Woman to Hospital

A two-vehicle collision sent a woman driving one of the vehicles to the hospital with a head injury Thursday afternoon in Fresno. Fresno pol...

10 minutes ago

A crash causes a traffic jam in northwest Fresno on Thursday, July 3, 2025. (GV Wire/Paul Marshall)
10 minutes ago

Fresno Crash Involving Unlicensed Teen Driver Sends Woman to Hospital

The Madre Fire near New Cuyama has burned 52,593 acres with 5% containment, prompting evacuation orders in several San Luis Obispo County zones as of Thursday, July 3, 2025, afternoon. (CalFire)
1 hour ago

Madre Fire Burns More Than 52,000 Acres in San Luis Obispo County

1 hour ago

RIP John Harris: Fresno County Rancher, Racehorse Breeder Was a Visionary Leader Who Leaves a ‘Profound Legacy’

2 hours ago

Valadao, Costa Spar on What Passage of Trump’s Bill Means for Medicaid Recipients

An ICE agent talks with migrants about their scheduled appointments with U.S. Immigration and Customs Enforcement (ICE) on Father’s Day, to learn about their immigration status, in Chicago, Illinois., U.S., June 15, 2025. (Reuters File)
2 hours ago

US Military Says 200 Marines Being Sent to Support ICE in Florida

Boeing logo and miniature satellite model are seen in this illustration taken, March 10, 2025. (Reuters File)
2 hours ago

Boeing Secures $2.8 Billion US Satellite Contract

3 hours ago

Kaweah Health Names Its New Chief Nurse. She’s From Texas

Clovis Police are searching for Pathmani Goonawardena, 82, who went missing nearly three weeks ago and was last seen driving a white Volvo near Copper and Auberry, possibly en route to Coarsegold. (CHP)
3 hours ago

Clovis Police Say At-Risk Missing Woman Found Dead in Mariposa County

Help continue the work that gets you the news that matters most.

Search

Send this to a friend