Dec 17, 2023; Glendale, Arizona, USA; San Francisco 49ers linebacker Fred Warner (54) leaps over San Francisco 49ers safety Tashaun Gipson Sr. (31) during the first quarter at State Farm Stadium. (Mark J. Rebilas-USA TODAY Sports)
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After defeating the Seattle Seahawks and New Orleans Saints to start their 2025 campaign with a 2-0 record, the San Francisco 49ers return home on Sunday for an NFC West battle with the Arizona Cardinals at Levi’s Stadium.
The 49ers looked solid in their win over the Saints last week despite quarterback Brock Purdy being sidelined with a toe injury. In his place, Mac Jones threw three touchdowns without an interception. At this point, it’s unclear who will be under center in Week 3, but either way San Francisco should be in a good spot.
Arizona has also started with two wins, downing the Saints and Carolina Panthers. Kyler Murray has thrown for nearly 400 yards and three touchdowns while running for another 70. This game will be a big test for them, as they look to knock San Francisco down a spot in the division.
Before these two teams meet on the field on Sunday afternoon, we’ve gone through picks from over 30 experts from eight different sites/publications to see who they’re taking in this matchup. Let’s take a look at what they said.
Here are all the top expert picks for 49ers vs. Cardinals in Week 3:
USA Today
- Jarrett Bell: Cardinals 20-17
- Nick Brinkerhoff: Cardinals 24-23
- Chris Bumbaca: 49ers 23-20
- Nate Davis: Cardinals 27-23
- Tyler Dragon: 49ers 21-17
- Mike Middlehurst-Schwartz: Cardinals 24-23
ESPN
- Stephanie Bell: 49ers
- Matt Bowen: 49ers
- Mike Clay: 49ers
- Jeremy Fowler: Cardinals
- Dan Graziano: Cardinals
- Kalyn Kahler: Cardinals
- Pamela Maldonado: 49ers
- Eric Moody: 49ers
- Jason Reid: Cardinals
- Lindsey Thiry: 49ers
- Seth Wickersham: 49ers
CBS Sports
- Pete Prisco: 49ers
- Cody Benjamin: Cardinals
- Jared Dubin: 49ers
- Ryan Wilson: 49ers
- John Breech: 49ers
- Tyler Sullivan: 49ers
- Dave Richard: 49ers
- Jamey Eisenberg: 49ers
The Sports Illustrated
- Clare Brennan: 49ers
- Mitch Goldich: 49ers
- Gilberto Manzano: Cardinals
- Conor Orr: 49ers
- John Pluym: 49ers
- Matt Verderame: Cardinals
Bleacher Report
- Ian Hanford: 49ers
- Kris Knox: 49ers
- Moe Moton: 49ers
- Brent Sobleski: Cardinals
- Gary Davenport: 49ers
- Brad Gagnon: Cardinals
- Wes O’Donnell: 49ers
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This article originally appeared on Niners Wire: 49ers vs. Cardinals picks: Who do experts predict will win Week 3 NFC West matchup?
Reporting by Mike Masala, Niners Wire / Niners Wire
USA TODAY Network via Reuters Connect
