Injuries are a major storyline in tonight’s Los Angeles Rams-San Francisco 49ers game because both teams are missing key starters. The 49ers already ruled out Brock Purdy, Ricky Pearsall and Jauan Jennings, while the Rams came into Thursday with Tyler Higbee and Rob Havenstein doubtful to play.

The Rams will officially be without those two players, as they’re on the team’s list of inactives for Thursday night. Additionally, Beaux Limmer, Desjuan Johnson and Stetson Bennett are also inactive, all three being healthy scratches.

With Higbee out, Terrance Ferguson is officially active for the first time since Week 2. He was a healthy scratch in each of the last two games and has played four total snaps on offense this season.

Los Angeles Rams Inactives

Inactives for Week 5 vs San Francisco:

QB Stetson Bennett IV
TE Tyler Higbee
OL Rob Havenstein
OL Beaux Limmer
DE Desjuan Johnson pic.twitter.com/acdXoH9ejt

— Los Angeles Rams (@RamsNFL) October 2, 2025

The 49ers previously ruled out five total players so their list of inactives features no real surprises. In addition to those five, Jordan James and Nick Martin are also inactive. C.J. West, who was questionable, is active.

San Francisco 49ers Inactives

Brock Purdy, Ricky Pearsall, and Jauan Jennings are inactive for Week 5.

Full @DignityHealth inactives list: https://t.co/YMP3dVvJMr pic.twitter.com/7OkxUPx2Rx

— San Francisco 49ers (@49ers) October 2, 2025

Kickoff is set for 8:15 p.m. ET tonight.

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This article originally appeared on Rams Wire: Rams vs. 49ers inactives: Who’s in, who’s out for Thursday Night Football
Reporting by Cameron DaSilva, Rams Wire / Rams Wire
USA TODAY Network via Reuters Connect