DUBAI, United Arab Emirates — Iran and Israel traded rounds of strikes late Saturday in the latest salvo since a surprise attack a day earlier aimed at decimating Tehran’s rapidly advancing nuclear program.

The latest U.S.-Iran talks regarding that program will not take place Sunday, officials said amid continued fighting. Iran launched a second round of missiles against Israel while Israel’s military kept up attacks in Iran following earlier strikes that targeted nuclear and military sites and killed key leaders in the country’s governing theocracy.

“Tehran is burning,” Israeli Defense Minister Israel Katz said on social media, and Iranian state television said explosions were heard in the city’s east and west.

Iran Launches Second Wave of Missile Attacks

Both Israel’s military and Iran state television announced the latest round of Iranian missiles as explosions were heard near midnight, while the Israeli security cabinet met. Iran’s paramilitary Revolutionary Guard in a statement said that Iranian missiles targeted facilities of production of fuel for Israeli jetfighters. It said Iran will fire further missiles if Israeli strikes continue.

The Magen David Adom emergency service said one woman was killed, with over a dozen others wounded, when a two-story home in the north was hit. Within the hour, Israel’s military said people could leave shelters.

Israel’s ongoing strikes across Iran have left the country’s surviving leadership with the difficult decision of whether to plunge deeper into conflict with Israel’s more powerful forces or seek a diplomatic route.

World leaders made urgent calls to deescalate and avoid all-out war. The attack on nuclear sites set a “dangerous precedent,” China’s foreign minister said. The region is already on edge as Israel makes a new push to eliminate the Iranian-backed militant group Hamas in Gaza after 20 months of fighting.

The sixth round of U.S.-Iran indirect talks on Sunday over Iran’s nuclear program will not take place, mediator Oman said. “We remain committed to talks and hope the Iranians will come to the table soon,” said a senior U.S. official, speaking on condition of anonymity to discuss diplomacy.

Nuclear Facilities Sustain Major Damage

Israel — widely believed to be the only nuclear-armed state in the Middle East — said its hundreds of strikes on Iran over the past two days have killed a number of top generals, nine senior scientists and experts involved in Iran’s nuclear program. Iran’s U.N. ambassador has said 78 people were killed and more than 320 wounded.

Prime Minister Benjamin Netanyahu, who has made the destruction of Iran’s nuclear program his top priority, said Israel’s strikes so far are “nothing compared to what they will feel under the sway of our forces in the coming days.”

In what could be another escalation if confirmed, semiofficial Iranian news agencies reported an Israeli drone struck and caused a “strong explosion” at an Iranian natural-gas processing plant. It would be the first Israeli attack on Iran’s oil and natural gas industry. Israel’s military did not immediately comment.

The extent of damage at the South Pars natural gas field was not immediately clear. Such sites have air defense systems around them, which Israel has been targeting.

Iran calls nuclear talks ‘unjustifiable’

Iran says its nuclear program is for peaceful purposes only, and U.S. intelligence agencies have assessed that Tehran was not actively pursuing the bomb. But its uranium enrichment has reached near weapons-grade levels, and on Thursday, the U.N.’s atomic watchdog censured Iran for not complying with obligations meant to prevent it from developing a nuclear weapon.

Iran’s top diplomat said Saturday the nuclear talks were “unjustifiable” after Israel’s strikes. Abbas Araghchi’s comments came during a call with Kaja Kallas, the European Union’s top diplomat.

The Israeli airstrikes were the “result of the direct support by Washington,” Araghchi said in a statement carried by the state-run IRNA news agency. The U.S. has said it isn’t part of the strikes.

On Friday, U.S. President Donald Trump urged Iran to reach a deal with the U.S. on its nuclear program, adding that “Iran must make a deal, before there is nothing left.”

International Response and Military Operations

Iran launched its first waves of missiles at Israel late Friday and early Saturday. The attacks killed at least three people and wounded 174, two of them seriously, Israel said. The military said seven soldiers were lightly wounded when a missile hit central Israel, without specifying where.

U.S. ground-based air defense systems in the region were helping to shoot down Iranian missiles, said a U.S. official who spoke on condition of anonymity to discuss the measures.

Israel’s main international airport said it will remain closed until further notice.

Earlier Saturday, Israel’s army spokesman, Brig. Gen. Effie Defrin, said Israel had attacked more than 400 “missile-related” and other targets across Iran, including 40 in Tehran, where dozens of fighter jets were “operating freely.” He said it was the deepest point Israel’s air force had operated.

A governor of Eastern Azerbaijan province in northwestern Iran said 30 troops and a rescuer had been killed there, with 55 others wounded. Gov. Bahram Sarmast’s remarks were the latest acknowledgment of mass casualties.

Iranian state television reported that air defenses were firing in the cities of Khorramabad, Kermanshah and Tabriz. Iran’s semiofficial Tasnim news agency reported a fire at Tehran’s Mehrabad International Airport.

Israel attacked Iran’s main nuclear enrichment facility in Natanz. Satellite photos analyzed by AP show extensive damage there. The images shot Saturday by Planet Labs PBC show multiple buildings damaged or destroyed. The structures hit include buildings identified by experts as supplying power to the facility.

U.N. nuclear chief Rafael Grossi told the Security Council that the above-ground section of the Natanz facility was destroyed. The main centrifuge facility underground did not appear to have been hit, but the loss of power could have damaged infrastructure there, he said.

Israel said it also struck a nuclear research facility in Isfahan, including “infrastructure for enriched uranium conversion,” and said it destroyed dozens of radar installations and surface-to-air missile launchers in western Iran. Iran confirmed the strike at Isfahan.

The International Atomic Energy Agency said four “critical buildings” at the Isfahan site were damaged, including its uranium conversion facility. “As in Natanz, no increase in off-site radiation expected,” it added.

An Israeli military official, speaking on condition of anonymity in line with official procedures, said that according to the army’s initial assessment “it will take much more than a few weeks” for Iran to repair the damage to the Natanz and Isfahan nuclear sites. The official said the army had “concrete intelligence that production in Isfahan was for military purposes.”

Israel denied it had struck the nuclear enrichment facility in Fordo, about 100 kilometers (60 miles) southeast of Tehran.

Among those killed were three of Iran’s top military leaders: one who oversaw the entire armed forces, Gen. Mohammad Bagheri; one who led the paramilitary Revolutionary Guard, Gen. Hossein Salami; and the head of the Guard’s aerospace division, which oversees its arsenal of ballistic missile program, Gen. Amir Ali Hajizadeh. On Saturday, Khamenei named a new leader for the Revolutionary Guard’s aerospace division: Gen. Majid Mousavi.

Lidman and Frankel reported from Jerusalem. Associated Press writers Natalie Melzer in Nahariya, Israel, and Nasser Karimi in Tehran, Iran, contributed to this report.