SANTA CLARA — San Francisco quarterback Brock Purdy took part in some light throwing on Monday after missing his first career game because of an injury and the 49ers are hoping he can return this week.

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Purdy hurt his throwing shoulder during a loss to Seattle on Nov. 17. Purdy underwent two MRIs last week that showed no structural damage. But Purdy he felt discomfort after making a few throws at practice on Thursday and was shut down for the game at Green Bay on Sunday that San Francisco lost 38-10.

Coach Kyle Shanahan said Monday that Purdy made it through the session without pain and will rest on Tuesday and hopefully be able to return to practice on Wednesday as the Niners prepare to play at Buffalo this coming week.

“We rested it throughout the weekend hoping that would help,” Shanahan said. “He threw lighter today to see if that rest helps and the rest did help him. So we’ll see again, going through the same things we did last week. We’re going to let him rest all the way up to Wednesday. We’ll see how it feels on Wednesday and then we’ll take the exact same course throughout the week. Hopefully it responds better this week than it did last week with the rest.”

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Brandon Allen Steps In for Injured Purdy

Brandon Allen went 17 for 29 for 199 yards with a touchdown, an interception and a lost fumble in his first start since the 2021 season. Allen would play once again if Purdy is unable to go on Sunday at Buffalo.

Purdy wasn’t the only star player missing for the 49ers on Sunday with defensive end Nick Bosa missing the game with injuries to his left hip and oblique and left tackle Trent Williams out with an ankle injury.

“Just waiting to see how they respond,” Shanahan said. “They didn’t respond great last week. That’s why they weren’t able to go. Nick and Trent are both in the same boat. … We’ll evaluate as this week progresses and hopefully it turns a better corner than it did last week.”

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Injury Updates for Key Players

In other injury news, linebacker Dre Greenlaw will return to practice this week for the first time since tearing his Achilles tendon in the Super Bowl last season. Greenlaw will likely need at least a couple of weeks of practice before being able to return to play.

Offensive lineman Jon Feliciano will be shut down for the rest of the season after his knee injury didn’t fully heal. Feliciano’s three-week practice window ended Monday and the Niners decided to keep him on injured reserve instead of activating him.

Left guard Aaron Banks, defensive tackle Jordan Elliott and receiver Jacob Cowing all remain in concussion protocol to start this week and their status is unknown.

Right guard Dominick Puni (shoulder) and cornerback Deommodore Lenoir (knee) underwent MRIs on Monday and the team is waiting for results.

Cornerback Renardo Green (neck) and linebacker Demetrius Flannigan-Fowles (knee) are day to day.

Defensive tackle Kevin Givens is expected to return to practice this week after missing the past four games with a groin injury.